PRENATAL STRESS DOWN-REGULATES REELIN EXPRESSION BY METHYLATION OF ITS PROMOTER AND INDUCES ADULT BEHAVIORAL IMPAIRMENTS IN RATS.

Prenatal stress down-regulates Reelin expression by methylation of its promoter and induces adult behavioral impairments in rats.

Prenatal stress causes predisposition to cognitive and emotional disturbances and is a risk factor towards the development of neuropsychiatric conditions like depression, bipolar disorders and schizophrenia.The extracellular protein Reelin, expressed by Cajal-Retzius cells during cortical development, plays critical roles on cortical lamination and

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Effectiveness of interventions designed to mitigate the negative health outcomes of informal caregiving to older adults: an umbrella review of systematic reviews and meta-analyses

Objectives This umbrella review aimed to evaluate whether certain interventions can mitigate the negative health consequences of caregiving, which interventions are more effective than others depending on the circumstances, and how these interventions are experienced by caregivers themselves.Design An umbrella review of systematic reviews was condu

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Ecological niche of plant pathogens

Disease ecology Lighting Adapter is a new approach to the understanding of the spread and dynamics of pathogens in natural and man-made environments.Defining and describing the ecological niche of the pathogens is one of the major tasks for ecological theory, as well as for practitioners preoccupied with the control and forecasting of established a

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Internal and external market orientation as organizational resources - consequences for market and financial performance

The concept of internal marketing has been discussed in marketing literature for over 30 years.Despite this fact there is little theoretical and empirical evidence of the way in which the internal market DC Brushless Fan orientation impacts market and financial performance.On the other hand, there is considerable empirical evidence concerning the i

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The social problems and the scientific education

The contemporary time is claiming a technological scientific formation that goes to overcome the conceptual reductionism, focus in the learning of certain system of scientific knowledge and of certain specific abilities of the science, in order to prosecute appropriately, with scientific-technological foundation, the problems that take place in its

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